A simple, efficient, precise and accurate spectroscopic method has been developed and validated for quantitative estimation of diclofenac sodiumin bulk and pharmaceutical dosage form. Diclofenac standard solution was scanned in the UV rang (400-200 nm) in a 1 cm quartz cell in a double beam UV spectrophotometer. The absorption maxima of diclofenac were found to be 276.20 nm. The method obeys beers law in the concentration range from 10- 30 μg/ml. The correlation coefficient was found to be 0.9995 and regression of the curve was found y = 0.0324x + 0.0021 with excellent recovery 98.72-99.86%. Limit of detection and limit of quantitation were found to be 1.03 mg/ml and 3.12 mg/ml respectively. The method was validated for several parameters like accuracy, precision as per ICH guidelines. Value of % RSD and % recovery was found satisfactory, hence the proposed method is precise, accurate and economical hence can be used for routine analysis of diclofenac sodium.
Loading....